Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases
Background: The COVID-19 pandemic is an emerging concern regarding the potential adverse effects during pregnancy. This study reviews knowledge on the impact of COVID-19 on pregnancy and describes the outcome of published cases of pregnant women diagnosed with COVID-19. Methods: Searches were conduc...
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2020-05-05
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| Acceso en línea: | https://doi.org/10.1101/2020.04.25.20079509 https://hdl.handle.net/20.500.12663/1657 |
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Rodrigues, Carina et al. 2020-06-01T15:07:20Z 2020-06-01T15:07:20Z 2020-05-05 https://doi.org/10.1101/2020.04.25.20079509 https://hdl.handle.net/20.500.12663/1657 Background: The COVID-19 pandemic is an emerging concern regarding the potential adverse effects during pregnancy. This study reviews knowledge on the impact of COVID-19 on pregnancy and describes the outcome of published cases of pregnant women diagnosed with COVID-19. Methods: Searches were conducted in PubMed up to 8 April 2020, using PRISMA standards, to identify original published studies describing pregnant women at any gestational age diagnosed COVID-19. There were no date or language restrictions on the search. All identified studies were included irrespective of assumptions on study quality. Results: We identified 30 original studies reporting 212 cases of pregnant women with COVID-19 (30 discharged while pregnant), 200 from China and 12 from other countries. The 182 published deliveries resulted in one stillbirth and 185 live births. Four women with severe COVID-19 required admission to an intensive care unit but no cases of maternal death were reported. There was one neonatal death. Preterm births occurred in 28.7% of cases, but it is unclear whether this was iatrogenic. All cases with amniotic fluid, placenta, and/or cord blood analyzed for the SARS-CoV-2 virus were negative. Four newborns were positive for SARS-CoV-2 and three newborns had high levels of IgM antibodies. Breast milk samples from 13 mothers and described in seven studies showed no evidence of SARS-CoV-2. Conclusion: The evidence related to the effect of COVID-19 on pregnant women is still limited. Pregnant women and newborns should be considered particularly vulnerable populations regarding COVID-19 prevention and management strategies. English COVID-19 Infectious Diseases Coronavirus Pregnancy Systematic Review Breast Feeding SARS-CoV Betacoronavirus Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases medRxiv Global (WHO/OMS) Epidemiology and epidemiological studies Published Article Slow Spread / Reducir la Dispersión |
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Organización Panamericana de la Salud |
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Organización Panamericana de la Salud |
| title |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases |
| spellingShingle |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases Rodrigues, Carina et al. COVID-19 Infectious Diseases Coronavirus Pregnancy Systematic Review Breast Feeding SARS-CoV Betacoronavirus |
| title_short |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases |
| title_full |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases |
| title_fullStr |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases |
| title_full_unstemmed |
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases |
| title_sort |
pregnancy and breastfeeding during covid-19 pandemic: a systematic review of published pregnancy cases |
| author |
Rodrigues, Carina et al. |
| author_facet |
Rodrigues, Carina et al. |
| topic |
COVID-19 Infectious Diseases Coronavirus Pregnancy Systematic Review Breast Feeding SARS-CoV Betacoronavirus |
| topic_facet |
COVID-19 Infectious Diseases Coronavirus Pregnancy Systematic Review Breast Feeding SARS-CoV Betacoronavirus |
| publishDate |
2020-05-05 |
| format |
Published Article |
| description |
Background: The COVID-19 pandemic is an emerging concern regarding the potential adverse effects during pregnancy. This study reviews knowledge on the impact of COVID-19 on pregnancy and describes the outcome of published cases of pregnant women diagnosed with COVID-19. Methods: Searches were conducted in PubMed up to 8 April 2020, using PRISMA standards, to identify original published studies describing pregnant women at any gestational age diagnosed COVID-19. There were no date or language restrictions on the search. All identified studies were included irrespective of assumptions on study quality. Results: We identified 30 original studies reporting 212 cases of pregnant women with COVID-19 (30 discharged while pregnant), 200 from China and 12 from other countries. The 182 published deliveries resulted in one stillbirth and 185 live births. Four women with severe COVID-19 required admission to an intensive care unit but no cases of maternal death were reported. There was one neonatal death. Preterm births occurred in 28.7% of cases, but it is unclear whether this was iatrogenic. All cases with amniotic fluid, placenta, and/or cord blood analyzed for the SARS-CoV-2 virus were negative. Four newborns were positive for SARS-CoV-2 and three newborns had high levels of IgM antibodies. Breast milk samples from 13 mothers and described in seven studies showed no evidence of SARS-CoV-2. Conclusion: The evidence related to the effect of COVID-19 on pregnant women is still limited. Pregnant women and newborns should be considered particularly vulnerable populations regarding COVID-19 prevention and management strategies.
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| url |
https://doi.org/10.1101/2020.04.25.20079509 https://hdl.handle.net/20.500.12663/1657 |
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AT rodriguescarinaetal pregnancyandbreastfeedingduringcovid19pandemicasystematicreviewofpublishedpregnancycases |
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